Fixed digital contractures revealing light-chain amyloidosis - 21/07/09
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Abstract |
Among the many clinical manifestations of light-chain (AL) amyloidosis, musculoskeletal involvement is rarely reported. We describe the case of a 72-year-old woman who was referred to our rheumatology department for fixed flexion contractures of the fingers that developed concomitantly with a decline in general health. Macroglossia and recent-onset dyspnea were noted. Investigations, which included a tongue biopsy, established the diagnosis of kappa light-chain amyloidosis with soft tissue, bone, and cardiac deposits. Melphalan and dexamethasone therapy was successful in stabilizing the clinical and laboratory abnormalities within 6 months. This case is remarkable in that the musculoskeletal manifestations were at the forefront of the clinical picture and led to the diagnosis.
Le texte complet de cet article est disponible en PDF.Keywords : Amyloidosis, Digital contractures, Osteolysis
Plan
Vol 76 - N° 4
P. 404-408 - juillet 2009 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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