Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text

Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates

  • You can purchase this item in Pay Per ViewPay per View - FAQ : 33,00 € Taxes included to order
    Pages Iconography Videos Other
    7 0 0 0

Nutrition clinique et métabolisme
Volume 14, n° 3
pages 194-200 (septembre 2000)
Doi : S0985-0562(00)80022-9
Médiateurs de l'inflammation : contrôle par les nutriments azotés
Control of inflammatory mediators by nitrogenous nutrients

Luc Cynober
 Service de biochimie, Hôtel-Dieu, AP-HP, Inserm U341 et laboratoire de biologie de la nutrition, EA 2498, Paris V, 75181 Paris cedex 04, France 

*Correspondance et tirés à part : L. Cynober, laboratoire de biochimie A, 1, place du Parvis Notre-Dame, 75181 Paris cedex 04.

La réaction inflammatoire comprend la production de cytokines qui exercent des actions locales et systémiques. Son contrôle dépend d'un équilibre subtil entre cytokines pro- et anti-inflammatoires. Les cellules impliquées (macrophages, polynucléaires neutrophiles et lymphocytes T) sont dépendantes de certains acides aminés pour exercer leur fonctionnalité. Dans ce contexte, des apports nutritionnels enrichis en glutamine, en arginine ou en leur précurseur commun, l'α-cétoglutarate d'ornithine (ACO), ont fait la preuve de leur efficacité dans la dysimmunité des états cataboliques. L'activité pro-cicatrisante de l'ACO est d'un intérêt particulier.

The full text of this article is available in PDF format.

The inflammatory reaction includes the production of cytokines which display both local and systemic activities. The inflammatory reaction is tightly controlled by an equilibrium between pro- and anti-inflammatory cytokines. Concerned cells (macrophages, polymorphonuclear cells and lymphocytes T) need a sufficient supply of certain amino acids to be fully functional. In this setting, diets supplemented with glutamine, arginine and their common precursor, ornithine α-ketoglutarate (OKG), have proved their efficiency counteracting the disimmunity induced by stress. The activity of OKG on wound healing is of special interest.

The full text of this article is available in PDF format.

Keyword : arginine, α-cétoglutarate d'ornithine, cytokines, glutamine, immunité

Keywords : arginine, ornithine α-ketoglutarate, cytokines, glutamine, immunity

© 2000  Published by Elsevier Masson SAS.
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Article Outline
You can move this window by clicking on the headline