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Revue Neurologique
Volume 165, n° 10
pages 739-741 (octobre 2009)
Doi : 10.1016/j.neurol.2009.07.012
What has positron emission tomography told us about the epileptogenic zone?
Que nous a apporté la tomographie d’émission de positons pour la localisation de la zone épileptogène ?

A. Hammers
MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College London, South Kensington, Hammersmith Hospital, London SW7 2DD, United Kingdom 


There is no one ligand for visualising “the epileptogenic zone”. Several PET ligands, however, can help by noninvasively or minimally invasively refining hypotheses regarding its location. Their relative merits depend not only on local availability and expertise, but also on epilepsy syndrome and overall diagnostic category. FDG, flumazenil (FMZ), alpha-methyl-tryptophan (AMT), the 5-HT1A ligands, and diprenorphine are discussed.

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Il n’existe pas de ligand unique permettant de visualiser « la zone épileptogène ». En revanche, plusieurs ligands peuvent être utiles pour affiner de façon peu ou non-invasive des hypothèses quant à sa localisation. Leurs avantages respectifs dépendent non seulement de leur disponibilité et des expertises locales, mais aussi du syndrome en question et de la catégorie diagnostique globale de l’épilepsie. Le FDG, le flumazénil, l’alpha-méthyl-tryptophane, les ligands 5-HT1A et la diprénorphine sont discutés.

The full text of this article is available in PDF format.

Keywords : Epileptogenic zone, PET, FDG, Flumazenil, Alpha-methyl-tryptophan, Diprenorphine

Mots clés : Zone épileptogène, TEP, FDG, Flumazénil, Alpha-méthyl-tryptophane, Diprénorphine

© 2009  Elsevier Masson SAS. All Rights Reserved.
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