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Archives de pédiatrie
Volume 11, n° 4
pages 340-343 (avril 2004)
Doi : 10.1016/j.arcped.2004.01.015
Received : 30 April 2003 ;  accepted : 19 January 2004
Diarrhée profuse révélatrice d'un neuroblastome hypersécrétant le vasoactive intestinal peptide
Intractable diarrhoea revealing a neuroblastoma hypersecreting the vasoactive intestinal peptide

B.  Bourgois a ,  F.  Boman b ,  B.  Nelken a ,  M.  Bonnevalle c ,  D.  Turck a *
aClinique de pédiatrie, hôpital Jeanne-de-Flandre, 2, avenue Oscar-Lambret, 59037 Lille, France 
bService d'anatomie et cytologie pathologiques, faculté de médecine, hôpital Calmette, France 
cClinique de chirurgie pédiatrique, hôpital Jeanne-de-Flandre, 2, avenue Oscar-Lambret, 59037 Lille, France 

*Auteur correspondant. Unité de gastro-entérologie, hépatologie et nutrition, hôpital Jeanne-de-Flandre, 2, avenue Oscar-Lambret, 59037 Lille, France.

Chez l'enfant, le syndrome WDHA (watery diarrhoea-hypokaliema-achlorhydria) est rare et habituellement dû à une tumeur neuroblastique hypersécrétant le vasoactive intestinal peptide (VIP). Nous rapportons le cas d'un syndrome WDHA secondaire à l'hypersécrétion de VIP et révélateur d'un neuroblastome chez une enfant âgée de 13 mois. Une diarrhée sécrétoire, caractérisée par la persistance de la diarrhée en dépit de l'arrêt de l'alimentation orale, a conduit à rechercher une tumeur neuroblastique chez l'enfant. Le taux sérique de VIP s'est rapidement normalisé après l'exérèse chirurgicale de la tumeur.

Mots clés  : Diarrhée ; Neuroblastome ; Vasoactive intestinal peptide.


In children, the watery diarrhoea-hypokalemia-achlorhydria (WDHA) syndrome is uncommon and usually due to a neuroblastic tumour hypersecreting the vasoactive intestinal peptide (VIP). We report a case of WDHA syndrome secondary to hypersecretion of VIP that revealed a neuroblastoma in a 13-month-old girl. A secretory diarrhoea, characterised by the persistence of diarrhoea despite the cessation of oral feeding, led to the search of a neuroblastic tumour in the patient. The serum concentration of VIP decreased to normal values soon after the surgical excision of the tumour.

Mots clés  : Diarrhea ; Neuroblastoma ; Vasoactive intestinal peptide ; Infant.

© 2004  Elsevier SAS. All Rights Reserved.

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