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Biomedicine and pharmacotherapy
Volume 64, n° 4
pages 240-248 (avril 2010)
Doi : 10.1016/j.biopha.2009.06.019
Received : 17 November 2008 ;  accepted : 7 June 2009
GMDP augments antitumor action of the CP/TNF⍺ combination in vivo

Elena E. Petrova a, , Maria A. Simonova a, Ravilya L. Komaleva a, Marina V. Britsina b, Tatiana M. Andronova a, Vladimir A. Nesmeyanov a, Tatiana I. Valyakina a
a Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10, Mikhlukho-Macklaya street, Moscow 117997, Russian Federation 
b Mechnikov Institute of Vaccines and Serums, Russian Academy of Medical Sciences, Moscow, Russian Federation 

Corresponding author.

We have shown that glucosaminyl muramyl dipeptide (GMDP) has been augmented the antitumor action of chemotherapy drug cisplatin and tumor necrosis factor-⍺ (TNF⍺) on the Ehrlich ascites carcinoma and melanoma B-16 mouse tumor models. The doses of cisplatin, TNF⍺ and GMDP and also the conditions of the drugs combination injection provided 100% survival of mice with Ehrlich ascites carcinoma were found. Furthermore, it was shown first that GMDP has been decreased toxicity of the cisplatin/TNF⍺ combination and normalized the changes in the experimental mice hematological parameters which were produced by the CP/TNF⍺ combination.

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Keywords : Glucosaminyl muramyl dipeptide, Chemotherapy, Tumor necrosis factor

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