Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text
Service d'aide à la décision clinique

Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates

  • You can purchase this item in Pay Per ViewPay per View - FAQ : 30,00 € Taxes included to order
    Pages Iconography Videos Other
    4 0 0 0

Annales de Dermatologie et de Vénéréologie
Volume 137, n° S1
pages 26-29 (avril 2010)
Doi : 10.1016/S0151-9638(10)70006-5
Acide hyaluronique et immunité
Hyaluronic acid and immunity

O. Dereure
Service de Dermatologie, Hôpital St-Eloi, 80 avenue A Fliche, 34295 Montpellier cedex 5, France 


L’acide hyaluronique, constituant essentiel de la matrice extracellulaire et plus particulièrement de la substance fondamentale des tissus conjonctifs, n’est pas une structure inerte mais est au contraire doué de propriétés biologiques importantes. En effet, il joue un rôle important dans divers processus physiologiques très fondamentaux qui font notamment intervenir la plasticité tissulaire, et en particulier dans l’inflammation, la réaction immunitaire, la cicatrisation et l’angiogenèse. Il est également très impliqué dans la migration des cellules tumorales et donc dans la diffusion métastatique des tumeurs. Ces différents aspects physiologiques ou non sont liés soit à une interaction avec des récepteurs cellulaires membranaires plus ou moins spécifiques, soit à la production de fragments d’acide hyaluronique, par exemple après un traumatisme local ou une inflammation, fragments qui ont un rôle propre dépendant de leur taille.

The full text of this article is available in PDF format.

Hyaluronic acid (HA), one of the main components of extra-cellular matrix and most notably of the fundamental substance of conjunctive tissues, is not an inert structure. Conversely, it displays important biological properties and plays a significant role in crucial physiological processes especially when cellular plasticity is involved such as inflammation, immune reactions, angiogenesis and would healing. It is also strongly involved in neoplastic cells migration and therefore in metastatic spreading of malignant tumours. These varied physiological functions are related either to interactions with specific or less specific cellular membrane receptors or to the production of HA fragments of different sizes, generated for example by local traumatism or inflammation, fragments displaying specific properties according to their size.

The full text of this article is available in PDF format.

Mots clés : Acide hyaluronique, Immunité, Inflammation, Cicatrisation

Keywords : Hyaluronic acid, Immunity, Inflammation, Wound healing

© 2010  Elsevier Masson SAS. All Rights Reserved.
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Article Outline