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Annales de Dermatologie et de Vénéréologie
Volume 137, n° S1
pages 40-43 (avril 2010)
Doi : 10.1016/S0151-9638(10)70008-9
Acide hyaluronique et pathologie inflammatoire, auto-immune et cardio-vasculaire
Hyaluronan in inflammation, auto-immunity and cardio-vascular diseases

P. Berbis
Service de Dermatologie, Hôpital Nord, Chemin des Bourrellys, 13015 Marseille, France 


L’acide hyaluronique (AH) est un glycosaminoglycanne de haut poids moléculaire impliqué dans de nombreuses fonctions physiologiques. L’AH intervient dans des processus pathologiques variés, notamment inflammatoires, néoplasiques, cardio-vasculaires. CD44 est le principal récepteur membranaire de l’AH. En pathologie inflammatoire, l’AH exerce des effets opposés en fonction de sa taille. Les polymères de haut poids moléculaire (PM) sont anti-angiogéniques, anti-inflammatoires et immunosuppresseurs. Les oligomères de faible PM sont à l’inverse angiogéniques, pro-inflammatoires et immunostimulants. L’AH est impliqué fortement dans le recrutement des leucocytes sur le lieu de l’inflammation (rôle du CD44).

Les données impliquant l’AH dans les phénomènes allergiques ou auto-immuns sont plus parcellaires. L’AH semble jouer un rôle important dans la pathogénie de l’athérosclérose.

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Hyaluronan (H) is an ubiquitous high-molecular size glycosaminoglycan involved in many physiological functions. Evidences are numerous implying H in various pathological pathways, such as inflammation, cancer cardio-vascular diseases. CD44 is the principal membrane cell receptor of H. In inflammation, H has size-specific different biological activities. The high molecular weight H are anti-angiogenic, anti-inflammatory and immunosuppressive. Smaller H oligomers are angiogenic, inflammatory and immuno-stimulatory. H is strongly involved in the recruitment of leucocytes at the site of inflammation (role of CD44). Data giving evidence for a role of H in allergic pathways and auto-immunity are scarce. H is implicated in pathogenetic process leading to atherosclerosis.

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Mots clés : Acide hyaluronique, Athérosclérose, Inflammation

Keywords : Hyaluronan, Atherosclerosis, Inflammation

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