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Joint Bone Spine
Volume 71, n° 4
pages 266-274 (juillet 2004)
Doi : 10.1016/j.jbspin.2003.09.010
Received : 14 October 2002 ;  accepted : 12 September 2003
Acetaminophen as symptomatic treatment of pain from osteoarthritis

Philippe  Bertin a * ,  Karim  Keddad b ,  Isabelle  Jolivet-Landreau b
aRheumatology and Therapeutics Department, CHU Dupuytren Teaching Hospital, 2, avenue Martin Luther-King, 87042 Limoges cedex, France 
b Aventis Pharma/Théraplix, Medical Affairs, 46 quai de la Rapée, 75590 Paris cedex 12, France 

*Corresponding author.

Osteoarthritis is a major public health burden. The incidence of osteoarthritis increases with advancing age. Symptomatic treatments aimed at alleviating the pain and thereby restoring joint function form the basis of the treatment. The chronic course requires long-term treatment with special attention to minimizing the side effects of drugs. Acetaminophen has a good risk/benefit ratio that has prompted international consensus panels to recommend its use as first-line therapy in dosages of up to 4 g/day. This review discusses safety and efficacy data from randomized double-blind trials of acetaminophen used to alleviate pain caused by osteoarthritis.

Mots clés  : Osteoarthritis ; Paracetamol ; Acetaminophen ; Pain.

© 2003  Elsevier SAS. All Rights Reserved.

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