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Joint Bone Spine
Volume 71, n° 4
pages 275-283 (juillet 2004)
Doi : 10.1016/j.jbspin.2003.06.005
Received : 24 Mars 2003 ;  accepted : 5 June 2003
Chronic autoimmune thyroiditis and rheumatic manifestations

Leonardo  Punzi a * ,  Corrado  Betterle b
aDivision of Rheumatology, Department of Medical and Surgical Sciences, University of Padova, Via Giustiniani 2, Padova 35128, Italy 
bEndocrine Unit, Department of Medical and Surgical Sciences, University of Padova, Italy 

*Corresponding author. Tel.: +39-049-8212190, +39-049-8212199; fax: +39-049-8212191.

A variety of rheumatic manifestations have been described in association with autoimmune thyroiditis. In the past, most of these manifestations were attributed to the underlying thyroid dysfunction, in particular hypothyroidism. However, a responsibility of the mechanisms involved in the autoimmunity rather than a direct action of thyroid hormones seems supported by the evidences that some rheumatic manifestations may occur even in euthyroid patients, or that they are more frequent in hypothyroid patient with autoimmune thyroiditis than in those without this disease. Rheumatic manifestations could be sometimes attributable to the autoimmune rheumatic diseases frequently associated with autoimmune thyroiditis, such as Sjögren's syndrome, rheumatoid arthritis, systemic lupus erythematosus, or scleroderma. Among the most important or frequent rheumatic manifestations there are a mild non-erosive variety of arthritis, polyarthralgia, myalgia, and sicca syndrome without a true Sjögren's syndrome. Although the possible pathogenesis of these manifestations is not completely established, some hypotheses may be proposed, including a role of autoantibodies characteristics of autoimmune thyroiditis, a possible overlap between autoimmune thyroiditis and some autoimmune rheumatic diseases, and a systemic inflammatory reaction associated with thyroiditis.

Mots clés  : Autoimmune thyroiditis ; Rheumatic manifestations ; Arthritis ; Arthralgia.

© 2004  Elsevier SAS. All Rights Reserved.

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