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Archives de pédiatrie
Volume 11, n° 3
pages 219-222 (mars 2004)
Doi : 10.1016/j.arcped.2003.12.018
Received : 20 Mars 2003 ;  accepted : 6 December 2003
Le syndrome d’hyperéosinophilie essentielle : à propos d’un cas chez un nourrisson
Idiopathic hypereosinophilic syndrome: a case report in an infant
 

P Leblond a, , S Lepers b, E Thebaud a, F Mazingue a, A Lambilliotte a, M Fournier c, B Nelken a
a Unité protégée A, hôpital Jeanne-de-Flandre, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France 
b Laboratoire d’immunologie, faculté de médecine, pôle recherche, CHRU de Lille, 59037 Lille cedex, France 
c Laboratoire d’hématologie, hôpital Calmette, CHRU de Lille, 59037 Lille cedex, France 

*Auteur correspondant.
Résumé

Nous rapportons un cas de syndrome d’hyperéosinophilie essentielle (SHE) chez un nourrisson, d’évolution favorable sous traitement par interféron alpha.

Observation. – Un enfant de cinq mois a été hospitalisé pour une hyperéosinophilie à 187 G/l, associée à une splénomégalie. Le bilan étiologique effectué écartait les causes parasitaires et allergiques. Le myélogramme et le caryotype médullaire éliminaient une leucémie. Le diagnostic de SHE a été porté, et un traitement par corticoïde a été débuté sans succès. La mise sous interféron alpha a permis d’obtenir une rémission complète.

Discussion. – Le SHE est exceptionnel chez l’enfant. Il ne doit pas être méconnu car il expose à des complications viscérales notamment cardiaques potentiellement graves, et peut évoluer vers une hémopathie maligne. Il justifie une prise en charge thérapeutique énergique afin de limiter l’éosinophilie, et un suivi hématologique et échocardiographique soutenu.

The full text of this article is available in PDF format.
Abstract

We report a case of idiopathic hypereosinophilic syndrome in a young child with favorable outcome after treatment with alpha-interferon.

Case report. – A 5-month-old boy presented with major eosinophilia (187 G/l) associated with splenomegaly. There was no evidence for parasitic or allergic disease. Acute leukemia was suspected but bone marrow smear and medullary caryotype were not compatible. Idiopathic hypereosinophilic syndrome was thus diagnosed. Corticotherapy was started and failed. Finally, complete remission was obtained with alpha-interferon treatment.

Conclusion. – Idiopathic hypereosinophilic syndrome is uncommon in children. Significant complications like cardiac dysfunction or hematologic malignancies can occur. Treatment has to be quickly started, in order to reduce eosinophilia. Haematological and echocardiographic follow-up are required.

The full text of this article is available in PDF format.

Mots-clé : Hyperéosinophilie, Interferon alpha, Syndrome d'hyperéosinophilie essentielle

Keywords : Hypereosinophilic syndrome, Interferon alpha, therapeutic use, Infant




© 2003  Published by Elsevier Masson SAS.
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