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Joint Bone Spine
Volume 77, n° S2
pages 107-112 (décembre 2010)
Doi : 10.1016/S1297-319X(10)70004-X
Osteoporosis and mortality

Ariane Leboime a, Cyrille B. Confavreux b, Nadia Mehsen c, Julien Paccou d, Claire David e, Christian Roux a,
a Université Paris-Descartes, Hôpital Cochin, Service de Rhumatologie B, 27, rue du faubourg Saint-Jacques, Paris, France 
b INSERM U831 et Université de Lyon, Service de Rhumatologie, Hospices Civils de Lyon, Lyon, France 
c CHU Pellegrin, Service de Rhumatologie, 1, place Amélie-Raba-Léon, Bordeaux, France 
d Département Universitaire de Rhumatologie, CHU, Hôpital Roger-Salengro, Lille, France 
e Service de Rhumatologie, CHU Hôpital Sud, 16, boulevard de Bulgarie, Rennes, France 

Corresponding author.

Osteoporosis is classified as a public health problem by healthcare authorities because it is associated with an increased risk of potentially serious fractures. Osteoporotic fractures are known to generate a heavy burden of morbidity and financial cost [1]. However, recent data indicate that some osteoporotic fractures are also associated with excess mortality. These data have led to public health measures such as the addition by the World Health Organization of fracture prevention to the list of public health priorities [2] and the update on hip fractures issued recently by the statistics department of the French ministry of health (DREES [3]). Hip fractures constitute the most severe complication of osteoporosis because they can induce permanent physical disability, loss of self-sufficiency, institutionalization and, above all, an increased risk of death. Interestingly, two recent publications support the hypothesis that optimal osteoporosis management may affect the risk of death. Here, we will review the main data linking osteoporotic fractures overall (as opposed to hip fractures only) and mortality.

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Keywords : Osteoporosis, Fractures, Mortality, Dose-effect, Time-effect

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