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Archives de pédiatrie
Volume 18, n° 2
pages 238-243 (février 2011)
Doi : 10.1016/j.arcped.2010.10.016
Un nouvel éclairage physiopathologique de la modulation de la réponse immune par les lactobacilles
New in light of immune modulation by probiotics bacteria and increase IL10 producing regulatory T cells

J.-P. Magny
Service de pneumologie et allergologie clinique, hôpital Armand-Trousseau, 26, avenue du Docteur-Arnold-Netter, 75571 Paris cedex 12, France 


Les études faites avec les probiotiques avaient retrouvé un bénéfice lors de leur utilisation que l’on attribuait à un effet barrière de la muqueuse intestinale. On tente ici une nouvelle explication physiopathologique étayée par des résultats murins et, chez l’homme. Les récepteurs DC-SIGN et TOLL de la cellule dendritique interfèrent dans la coprésentation d’antigènes et suscitent une modulation de la réponse immune par les cellules T régulatrices et leurs cytokines inhibitrices TGFβ et IL10.

The full text of this article is available in PDF format.

Studies on probiotics had found a benefit in their use. That was attributed to a barrier effect at the intestinal mucosa. We tried a new immunephysiological explanation supported by murine works and in humans. Immune modulation by probiotic bacteria and induce IL10 producing regulatory T cells. Receptors DCSIGN and Toll dendrites cells interfere in the copresentation of antigens and generate an immune response modulation by regulatory T cells and their inhibitory cytokines TGFβ, IL10.

The full text of this article is available in PDF format.

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