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Archives de pédiatrie
Volume 18, n° S1
pages 42-47 (mai 2011)
Doi : 10.1016/S0929-693X(11)70939-3
Pharmacocinétique et pharmacodynamie des antifongiques en pédiatrie
Pharmacokinetics and pharmacodynamics of antifungal drugs in children
 

V. Jullien
Université Paris Descartes, Inserm U 663, Service de Pharmacologie Clinique, Hôpital Saint-Vincent de Paul, 74–82, avenue Denfert-Rochereau, 75014 Paris, France 

Résumé

Les principaux antifongiques utilisés dans les infections fongiques invasives (amphotéricine B, flucytosine, triazolés, echinocandines) ont été évalués de façon plus ou moins complète dans la population pédiatrique. Cet article passe en revue les profils pharmacocinétiques des différentes molécules chez l’enfant en mettant l’accent sur les modifications liées à l’âge. Les relations concentration/effet déterminées chez l’enfant sont également décrites.

The full text of this article is available in PDF format.
Summary

The pharmacokinetics and pharmacodynamics of the main antifungal drugs used for invasive fungal infections (amphotéricin B, flucytosine, triazole compounds, echinocandins) have been more or less completely investigated in the paediatric population. This article reviews the pharmacokinetic profiles of these drugs in children, with a focus on the age-related changes. The concentration/efficacy relationships that were evidenced in children are also described.

The full text of this article is available in PDF format.


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