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Archives de pédiatrie
Volume 18, n° S1
pages 8-14 (mai 2011)
Doi : 10.1016/S0929-693X(11)70935-6
Infections fongiques et déficits immunitaires héréditaires
Fungal infections and congenital immune deficiencies
 

J. Bustamante 1, 2, N. Mahlaoui 3, J.-L. Casanova 1, 2, 4, 5, S. Blanche 4, 5,
1 Laboratoire de Génétique Humaine des Maladies Infectieuses, Branche Necker, Institut National de la Santé de la Recherche Médicale U980, 75015 Paris, France 
2 Université Paris Descartes, Faculté de Médecine Necker, 75015 Paris, France 
3 Centre d’Etude et de Recherche sur les Déficits Immunitaires Héréditaires, Hôpital Necker-Enfants-Malades, 149, rue de Sèvres, 75015 Paris, France 
4 Saint Giles, Laboratoires de Génétique Humaine des Maladies Infectieuses, Branche Rockfeller, Université Rockfeller, New York 10065, États-Unis 
5 Unité d’Immunologie, Hématologie et Rhumatologie Pédiatriques, Hôpital Necker-Enfants-Malades, 149, rue de Sèvres, 75015 Paris, France 

Auteur correspondant.
Résumé

Différents types de déficits immunitaires constitutionnels exposent au risque d’infections fongiques sévères. Ces infections peuvent être révélatrices du déficit. Le type de micro-organismes impliqués, la présentation clinique, la réaction immune observée autour du germe peuvent alors orienter le diagnostic étiologique. Comme souvent dans le domaine des déficits immunitaires, les avancées dans leur physiopathologie apportent des informations capitales sur les mécanismes de défense naturelle contre ces micro-organismes. Les progrès thérapeutiques ont considérablement amélioré le pronostic de ces infections potentiellement graves, chroniques et invalidantes.

The full text of this article is available in PDF format.
Summary

Different types of hereditary immune deficiencies are at risk of severe fungal infections. Such infections can reveal the deficit. The type of micro-organisms involved, the clinical presentation, the immune reaction observed around the germ can then guide the etiological diagnosis. As often in the field of immunodeficiencies, advances in the pathophysiology provide crucial informations on the natural defense mechanisms against these organisms. Therapeutic advances have dramatically improved the prognosis of these potentially serious and disabling infections.

The full text of this article is available in PDF format.


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