4 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text

Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates

  • You can purchase this item in Pay Per ViewPay per View - FAQ : 30,00 € Taxes included to order
    Pages Iconography Videos Other
    6 4 0 0

Joint Bone Spine
Volume 78, n° 4
pages 358-363 (juillet 2011)
Doi : 10.1016/j.jbspin.2010.10.008
accepted : 18 October 2010
Detection of basic calcium phosphate crystals in osteoarthritis

Paul MacMullan a, Gillian McMahon b, Geraldine McCarthy a, , c
a Dept of Molecular and Cellular Therapeutics, RCSI, Dublin 2, Ireland 
b School of Chemical Sciences, DCU, Dublin 9, Ireland 
c Rheumatology Dept, Mater Misericordiae University Hospital, Dublin 7, Ireland 

Corresponding author. Tel.: +353 1 8032000; fax: +353 1 8034148.

Osteoarthritis (OA) is the most common human joint disorder. Its complex pathogenesis remains poorly understood but appears multifactorial. To date, no specific pharmacological agent has been identified to alter the disease course of OA. Calcification of articular cartilage is a hallmark of OA and evidence suggests it contributes directly to joint degeneration. Calcium crystals are frequently found in OA synovial fluid but their exact role in the disease process is unclear. Basic calcium phosphate (BCP) crystals are the predominant crystal type found in OA and recent data indicate a pathogenic role for these crystals in OA. However, information on the exact frequency and distribution of BCP crystals vary considerably, mainly due to the lack of simple and reliable methods of detection. The purpose of this review is to describe the current available methods for detecting BCP crystals and to highlight their obvious advantages and limitations. Recent developments in the field are also discussed with particular reference to their potential clinical applicability. Improved methods of detection for BCP crystals could potentially aid the diagnosis of OA and the development of novel therapies.

The full text of this article is available in PDF format.

Keywords : Osteoarthritis (OA), Basic calcium phosphate (BCP), Crystals

© 2010  Société française de rhumatologie@@#104156@@
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Article Outline