The role of leukocyte-stromal interactions in chronic inflammatory joint disease - 01/01/04

Doi : 10.1016/j.jbspin.2004.03.009

Angela Burman ^a ^¹

¹ These two authors contributed equally to this work.

, Oliver Haworth ^a ^{¹¹
These two authors contributed equally to this work.} , Paul Bradfield ^a ^{²²
Present address: Department of Pathology, University of Geneva, Switzerland.} , Greg Parsonage ^a , Andrew Filer ^a , Andrew M.C. Thomas ^b , Nicole Amft ^a , Mike Salmon ^a , Christopher D. Buckley ^a ^*

*Corresponding author. Tel.: +44-121-414-4383; fax: +44-121-414-6794.

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Résumé

Rheumatoid arthritis (RA) is a debilitating, chronic, persistent inflammatory disease that is characterised by painful and swollen joints. The aetiology of RA is unknown, however whereas past research has concentrated on the role of immune or inflammatory infiltrating cells in inflammation, it is becoming clear that stromal cells play a critical part in regulating the quality and duration of an inflammatory response. In this review we assess the role of fibroblasts within the inflamed synovium in modulating immune responses; in particular we examine the role of stromal cells in the switch from resolving to persistent inflammation as is found in the rheumatoid synovium.

Mots clés : Rheumatoid arthritis ; Cytokines ; Chemokines ; Synovitis ; Inflammation.