Interferon-gamma levels in familial Mediterranean fever - 01/01/04
Seyfettin
Köklü
a
*
,
Mehmet Akif
Öztürk
b
,
Mustafa
Balci
c
,
Osman
Yüksel
a
,
Ihsan
Ertenli
d
,
Sedat
Kiraz
d
*Corresponding author. Present address: Sögütözü caddesi, Atatepe sitesi, B2 blok, 34/28, 06510 Sögütözü, Ankara, Turkey. Tel.: +90-312-286-3998; fax: +90-312-312-4120.
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Résumé |
Aims. - To evaluate the levels of endogenous interferon-gamma (IFN-γ) in patients with familial Mediterranean fever (FMF).
Methods. - Plasma levels of IFN-γ were assayed in 29 FMF patients in attack-free period (mean age: 32, min-max: 17-48; male/female: 10/19), 18 FMF patients with acute FMF attack (mean age: 32, min-max: 19-50; male/female: 8/10), and 19 healthy controls (mean age: 31.94 ± 1.50, min-max: 23-42; male/female: 11/8). IFN-γ levels were also compared among colchicine treated and untreated groups.
Results. - Median plasma IFN-γ levels were significantly higher in patients both with and without FMF attack than the control group (P < 0.05). Moreover, plasma IFN-γ levels were higher in patients with acute FMF attack compared to patients in attack-free periods (P < 0.05). Plasma levels of IFN-γ were comparable in colchicine treated and untreated groups.
Conclusion. - Our results suggest that IFN-γ may contribute to the inflammatory cascade of FMF.
Mots clés : Familial Mediterranean fever ; Interferon-gamma ; Polymorphonuclear leukocyte ; MEFV gene ; Marenostrin gene.
Plan
Vol 72 - N° 1
P. 38-40 - janvier 2005 Retour au numéro
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