Sebaceous lesions and their associated syndromes: Part I - 07/08/11

Doi : 10.1016/j.jaad.2009.04.058

Daniel B. Eisen, MD ^a,^⁎ , Daniel J. Michael, MD, PhD ^b
^a Department of Dermatology at the School of Medicine, University of California, Davis, Sacramento, California
^b Department of Dermatology, Kaiser Permanente, Walnut Creek, California

Reprint requests: Daniel B. Eisen, MD, Department of Dermatology, University of California, Davis, School of Medicine, 3301 C St, Ste 1400, Sacramento, CA 95816.

Abstract

Sebaceous neoplasms have long been a source of confusion to dermatologists and pathologists alike. Disagreements regarding nomenclature, classification, and management have been longstanding. Sebaceous lesions represent a broad spectrum of interesting entities that range from hamartomas, hyperplasias, and benign tumors to highly malignant neoplasms. This article discusses the clinical and pathologic features of sebaceous hyperplasia, nevus sebaceous of Jadassohn, sebaceous adenoma, seboacanthoma, sebaceous epithelioma, sebaceoma, mantleoma, basal cell carcinoma with sebaceous differentiation, sebomatricoma (sebomatrixoma), and sebaceous carcinoma. Controversies regarding these lesions will be explored, and any relationship with Muir–Torre syndrome will be discussed.

Learning objectives

After completing this learning activity, participants should be able to discuss controversies regarding the nomenclature of sebaceous neoplasms, discuss management strategies regarding nevus sebaceous of Jadassohn, and counsel patients about which sebaceous lesions are associated with Muir–Torre syndrome.

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Key words : epidermal nevus syndrome, hereditary nonpolyposis coli cancer syndrome, linear nevus sebaceous syndrome, Lynch syndrome, Muir–Torre syndrome, nevus sebaceous of Jadassohn, sebaceoma, sebaceous adenoma, sebaceous carcinoma, sebaceous epithelioma, sebaceous hyperplasia, sebomatrixoma

Abbreviations used : BCC, BCC-SD, MTS, NSJ, SA, SC, SH