Cutaneous side effects of anti–tumor necrosis factor biologic therapy: A clinical review - 07/08/11

Doi : 10.1016/j.jaad.2008.10.060

Aikaterini-Evaggelia Moustou, MD ^a, Athina Matekovits, MD ^a, Clio Dessinioti, MD ^a, Christina Antoniou, MD ^a, Petros P. Sfikakis, MD ^b, Alexander J. Stratigos, MD ^a,^⁎
^a 1st Department of Dermatology, Andreas Sygros Hospital, University of Athens Medical School, Athens, Greece
^b 1st Department of Propaedeutic and Internal Medicine, Laiko General Hospital, University of Athens Medical School, Athens, Greece

Reprint requests: Alexander J. Stratigos, MD, Andreas Sygros Hospital, 5 Dragoumi Street, Athens 10671, Greece.

Abstract

Background

Anti-tumor necrosis factor (anti-TNF) biologic agents have been associated with a number of adverse events.

Objective

To review the cutaneous reactions that have been reported in patients receiving anti-TNF therapy.

Methods

We performed a systematic MEDLINE search of relevant publications, including case reports and case series.

Results

Reported cutaneous events included infusion and injection site reactions, psoriasiform eruptions, lupus-like disorders, vasculitis, granulomatous reactions, cutaneous infections, and cutaneous neoplasms. Infusion reactions and injection site reactions were definitely associated with anti-TNF administration, whereas all other events had a varying strength of association and severity, not necessarily requiring drug discontinuation.

Limitations

Most information was derived from spontaneous case reports, where ascertainment biases and frequency of reporting may impair detection methodology and causal relationships.

Conclusions

As anti-TNF biologic agents are progressively being used in clinical practice, cutaneous adverse events will be encountered more frequently. Until more data are accumulated with respect to their pathogenesis and potential association with anti-TNF therapy, dermatologists should become more familiar with the clinical presentation and management of such events.

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Abbreviations used : AD, ANA, CD, CTCL, DMARD, dsDNA, HR, IGD, LCV, LE, NMSC, PUVA, RA, SLE, TNF, UVB