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Journal of the American Academy of Dermatology
Volume 61, n° 5
pages 888-891 (novembre 2009)
Doi : 10.1016/j.jaad.2009.02.007
Case Reports

Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma

Maymi Kato, MD a, Koichi Ohshima, MD, PhD d, Masahiro Mizuno, MD b, Masahisa Kyogoku, MD, PhD c, Keiko Hashikawa, MD d, Yoshiki Tokura, MD, PhD e, Yoshiki Miyachi, MD, PhD f, Kenji Kabashima, MD, PhD f,
a Division of Dermatology, Mitsubishi Hospital, Kyoto, Japan 
b Division of Internal Medicine, Mitsubishi Hospital, Kyoto, Japan 
c Division of Pathology, Mitsubishi Hospital, Kyoto, Japan 
d Department of Pathology, School of Medicine, Kurume University, Kurume, Japan 
e Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan 
f Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan 

Correspondence to: Kenji Kabashima, MD, PhD, Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawara, Sakyo, Kyoto, 606-8507, Japan.

Intravascular large B-cell lymphoma is a rare disease with multiorgan involvement that also affects the skin. Skin manifestations include purpuric to red macules, plaques, or nodules with occasional edema and tenderness. We report a 68-year-old woman with bilateral leg edema and occasional high fever. A biopsy specimen from a subcutaneous nodule showed that the blood vessels in the dermis and subcutaneous tissue were filled with irregularly shaped chromatin-rich large atypical lymphocytes positive for CD20 and bcl-2, consistent with the diagnosis of intravascular large B-cell lymphoma. In addition, immunohistochemical analysis showed expression of CXCR3 in the atypical lymphocytes; its ligand, CXCL9, was detected in blood vessels. Although limited to a single case, our study could provide a possible new clue to the pathogenesis of intravascular large B-cell lymphoma by virtue of the characteristic expression of CXCL9-CXCR3.

The full text of this article is available in PDF format.

Key words : chemokine, chemokine receptor, CXCL9, CXCR3, intravascular large B-cell lymphoma, skin

 Funding sources: None.
 Conflicts of interest: None declared.
 Reprints not available from the authors.

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