Article

2 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text
Advertising


Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates



Journal of the American Academy of Dermatology
Volume 61, n° 5
pages 888-891 (novembre 2009)
Doi : 10.1016/j.jaad.2009.02.007
Case Reports

Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma
 

Maymi Kato, MD a, Koichi Ohshima, MD, PhD d, Masahiro Mizuno, MD b, Masahisa Kyogoku, MD, PhD c, Keiko Hashikawa, MD d, Yoshiki Tokura, MD, PhD e, Yoshiki Miyachi, MD, PhD f, Kenji Kabashima, MD, PhD f,
a Division of Dermatology, Mitsubishi Hospital, Kyoto, Japan 
b Division of Internal Medicine, Mitsubishi Hospital, Kyoto, Japan 
c Division of Pathology, Mitsubishi Hospital, Kyoto, Japan 
d Department of Pathology, School of Medicine, Kurume University, Kurume, Japan 
e Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan 
f Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan 

Correspondence to: Kenji Kabashima, MD, PhD, Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawara, Sakyo, Kyoto, 606-8507, Japan.
Abstract

Intravascular large B-cell lymphoma is a rare disease with multiorgan involvement that also affects the skin. Skin manifestations include purpuric to red macules, plaques, or nodules with occasional edema and tenderness. We report a 68-year-old woman with bilateral leg edema and occasional high fever. A biopsy specimen from a subcutaneous nodule showed that the blood vessels in the dermis and subcutaneous tissue were filled with irregularly shaped chromatin-rich large atypical lymphocytes positive for CD20 and bcl-2, consistent with the diagnosis of intravascular large B-cell lymphoma. In addition, immunohistochemical analysis showed expression of CXCR3 in the atypical lymphocytes; its ligand, CXCL9, was detected in blood vessels. Although limited to a single case, our study could provide a possible new clue to the pathogenesis of intravascular large B-cell lymphoma by virtue of the characteristic expression of CXCL9-CXCR3.

The full text of this article is available in PDF format.

Key words : chemokine, chemokine receptor, CXCL9, CXCR3, intravascular large B-cell lymphoma, skin



 Funding sources: None.
 Conflicts of interest: None declared.
 Reprints not available from the authors.



© 2009  American Academy of Dermatology, Inc.@@#104156@@
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline
You can move this window by clicking on the headline