Methotrexate-related lymphoproliferative disorder with extensive vascular involvement in a patient with rheumatoid arthritis - 07/08/11
Abstract |
We describe the development of a cutaneous lymphoproliferative disorder in a patient with rheumatoid arthritis who was treated with methotrexate. Skin manifestations were characterized by thrombophlebitis-like lesions and ulcerated nodules. Histologic examination revealed large polymorphic atypical cells including Reed-Sternberg–like cells expressing CD20 and CD30 in the dermis and subcutaneous tissues. Tumor cells infiltrated the walls of dermal arterioles, subcutaneous arteries, and veins, leading to the destruction of vascular structures. Activation of Epstein-Barr virus was detected. Skin lesions improved remarkably after the discontinuation of methotrexate. This case illustrates the rare occurrence of cutaneous vascular involvement in methotrexate-related lymphoproliferative disorder that did not require any specific chemotherapy.
Le texte complet de cet article est disponible en PDF.Key words : EB virus, Hodgkin lymphoma, methotrexate, thrombophlebitis
Abbreviations used : EB, HL, LPD, MTX, MTX-LPD, RA
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
Vol 61 - N° 1
P. 126-129 - juillet 2009 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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