Poor prognosis in non-Caucasian patients with early-onset mycosis fungoides - 08/08/11
Reprint requests: Madeleine Duvic, MD, Department of Dermatology, University of Texas M.D. Anderson Cancer Center, 1452 Holcombe Blvd, Box 1452, Houston, TX 77030-4009.Abstract |
Background |
Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma, is most often seen in middle-aged to elderly men.
Objective |
We conducted a retrospective study of the demographics and prognosis of patients with onset of MF before age 40 years.
Methods |
Demographic data (age, sex, and race) and histology from 1074 patents with cutaneous T-cell lymphoma were stratified by age of onset and race and analyzed using Chi-square test.
Results |
Women presented before age 40 years more often than men (P = .038). Early onset of MF was diagnosed in 30 of 92 (32.6%) African American (AA), 31 of 87 (35.6%) Hispanic, and 103 of 809 (12.7%) Caucasian patients. MF was significantly more common in AA (P = .0008) and Hispanic (P = .0002) patients. Early-onset MF was more common among 21 of 60 AA women (35%, P = .0174) and 19 of 40 Hispanic women (47.5%, P = .0002) than among 50 of 350 Caucasian women (14.5%). Progression from initial TNM stage occurred in only 5 (10%) Caucasian, one (5%) Hispanic, and 8 (38%) AA women who presented before age 40 years. Six of 8 AA women who progressed died of their disease whereas two were long-term survivors after allogeneic transplantation.
Limitations |
This was a retrospective study at one cancer center.
Conclusion |
Although MF is considered to be a disease of middle-aged men, early-onset MF is more common among AA and Hispanic women. AA women with early onset may have a poor prognosis and should be considered for more aggressive therapy, including allogeneic transplantation.
Le texte complet de cet article est disponible en PDF.Abbreviations used : AA, CTCL, MF
Plan
| Supported in part by Sherry L. Anderson Cutaneous T-cell Lymphoma Research Fund, the National Institutes of Health grant K24-CA86815 (Dr Duvic), and M.D. Anderson Core Grant CA16672. |
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| Conflicts of interest: None declared. |
Vol 60 - N° 2
P. 231-235 - février 2009 Retour au numéro
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