The specific dermatoses of pregnancy revisited and reclassified: Results of a retrospective two-center study on 505 pregnant patients - 09/08/11
, Robert R. Müllegger, MD a, Samantha A. Vaughan-Jones, MD b, Helmut Kerl, MD a, Martin M. Black, MD, FRCP, FRCPath b
Reprint requests: Christina M. Ambros-Rudolph, MD, Department of Dermatology, Medical University Graz, Auenbruggerplatz 8, A-8036 Graz, Austria.Graz, Austria, and London, United Kingdom
Abstract |
Objectives |
We sought to evaluate the frequency and clinical characteristics of pruritic dermatoses in pregnancy and to assess a rationalized classification.
Methods |
Data of 505 pregnant patients seen at two university-based dermatologic hospitals (1994-2004) were retrospectively studied.
Results |
Diagnoses included eczema in pregnancy (49.7%), polymorphic eruption of pregnancy (PEP) (21.6%), pemphigoid gestationis (PG) (4.2%), intrahepatic cholestasis of pregnancy (ICP) (3%), prurigo of pregnancy (0.8%), pruritic folliculitis of pregnancy (0.2%), and miscellaneous dermatoses (20.6%). Eczema in pregnancy, prurigo of pregnancy, and pruritic folliculitis of pregnancy showed considerable overlap and were summarized as atopic eruption of pregnancy (AEP). While PEP, PG, and ICP presented in late pregnancy, AEP started significantly earlier. Primigravidae and multiple gestations were characteristic for PEP, abdominal involvement for PEP and PG, and a history of affected pregnancies for ICP.
Limitations |
This was a retrospective study.
Conclusion |
We propose classifying the dermatoses of pregnancy as PG, PEP, AEP, and ICP. Stereotypic immunofluorescence and laboratory findings are diagnostic of PG and ICP, whereas distinct clinical characteristics facilitate discrimination between PEP and AEP.
Le texte complet de cet article est disponible en PDF.Abbreviations used : AEP, EP, ICP, IMF, PEP, PF, PG, PP
Plan
| Funding sources: None. Conflicts of interest: None identified. |
Vol 54 - N° 3
P. 395-404 - mars 2006 Retour au numéro
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