Minimal residual disease in hypopigmented mycosis fungoides - 09/08/11
, Shiou-Hwa Jee, MD, PhD d
Reprint requests: Tsen-Fang Tsai, MD, Department of Dermatology, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei 100, Taiwan.Taipei, Taiwan
Abstract |
We describe the case of a 13-year-old boy with stage I hypopigmented mycosis fungoides in whom minimal residual disease was detected with T-cell receptor γ-polymerase chain reaction after the disease was in complete clinical remission. We further cloned and sequenced the T-cell receptor γ-polymerase chain reaction product of the lesion in remission and found that the original T-cell clone still existed in decreased amounts. The patient was followed up for 3 1/2 years without any new lesions developing. The clinical significance of this residual malignant T-cell clone in mycosis fungoides remains to be elucidated.
Le texte complet de cet article est disponible en PDF.Abbreviations used : PCR, MF, MRD, TCR
Plan
| Supported by Stiefel Laboratories. Funding sources: None. Conflicts of interest: None identified. |
Vol 54 - N° 5S
P. S198-S201 - mai 2006 Retour au numéro
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