Photoaging: Mechanisms and repair - 09/08/11

Doi : 10.1016/j.jaad.2005.05.010

Jessica H. Rabe, MD, Adam J. Mamelak, MD, Patrick J.S. McElgunn, MD, Warwick L. Morison, MD ^⁎ , Daniel N. Sauder, MD
From the Department of Dermatology, Johns Hopkins University

Reprint requests: Warwick L. Morison, MD, Johns Hopkins at Green Spring, 10753 Falls Road, Suite 355, Lutherville, MD 21093.

Baltimore, Maryland

Abstract

Aging is a complex, multifactorial process resulting in several functional and esthetic changes in the skin. These changes result from intrinsic as well as extrinsic processes, such as ultraviolet radiation. Recent advances in skin biology have increased our understanding of skin homeostasis and the aging process, as well as the mechanisms by which ultraviolet radiation contributes to photoaging and cutaneous disease. These advances in skin biology have led to the development of a diversity of treatments aimed at preventing aging and rejuvenating the skin. The focus of this review is the mechanism of photoaging and the pathophysiology underlying the treatments specifically designed for its prevention and treatment.

Learning objectives

At the conclusion of this learning activity, participants should be familiar with the mechanism of photoaging, the treatments for photoaging, and the data that supports the use of these treatments.

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Abbreviations used : AHA, AP, CoQ₁₀, CO₂, GA, GTP, HA, IL, MMP, NF, RA, RAR, ROS, RXR, SNAP, SPF, TGF, TIMP, TNF, UPF, UV, YAG

Plan

Supported by an educational grant from Connetics Corporation (to A. J. M).
Disclosure: Dr Sauder is a consultant for Amgen, Biogen, Centecor, Genentech, and Abbott Laboratories. Dr. McElgunn has received research funding from Syneron Medical Ltd and is a consultant for Advanced Aesthetic Institute Inc, Allergan, and Medicis.