Acne in recipients of renal transplantation treated with sirolimus: Clinical, microbiologic, histologic, therapeutic, and pathogenic aspects - 09/08/11
Doi : 10.1016/j.jaad.2005.11.1072
Emmanuel Mahé, MD a, b, ⁎ 
, Emmanuel Morelon, MD, PhD c, d, Sophie Lechaton c, Jean-Christophe Drappier, MD a, Yves de Prost, MD a, Henri Kreis, MD c, Christine Bodemer, MD, PhD a
, Emmanuel Morelon, MD, PhD c, d, Sophie Lechaton c, Jean-Christophe Drappier, MD a, Yves de Prost, MD a, Henri Kreis, MD c, Christine Bodemer, MD, PhD a a From the Departments of Dermatology
c Transplantation, Necker-Enfants Malades University Hospital, Paris
b Department of Dermatology, Bichat-Claude Bernard University Hospital, Paris
d Department of Nephrology, Transplantation, and Clinical Immunology, Edouard Herriot University Hospital, Lyon
Reprint requests: Emmanuel Mahé, MD, Service de Dermatologie, Hôpital Ambroise Paré, 9 Avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France.Paris and Lyon, France
Abstract |
We evaluated the clinical characteristics of sirolimus-induced acne in 80 recipients of renal transplantation. It developed in 36 of 48 (75%) men and 2 of 32 (6%) women. Lesion locations and clinical, bacteriologic, and histologic features differentiated sirolimus-induced acne from acne vulgaris, but therapeutic management was similar. The main limitation for this study was the absence of a control group without sirolimus. Epidermal growth factor inhibition by sirolimus is a plausible explanation for this acne.
Le texte complet de cet article est disponible en PDF.Plan
| Funding sources: None. Disclosure: Drs Morelon and Kreis are investigators in sirolimus trials conducted among recipients of renal transplantation. |
© 2006
American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 55 - N° 1
P. 139-142 - juillet 2006 Retour au numéro
Article précédent
- Incontinentia pigmenti in a boy with XXY mosaicism detected by fluorescence in situ hybridization
- Luis M. Franco, Jennifer Goldstein, Neil S. Prose, M. Angélica Selim, Carlos A. Tirado, Melissa M. Coale, Marie T. McDonald
- Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) associated with pemphigoid nodularis: A case report and review of the literature
- Jamie L. McGinness, Mary-Margaret C. Bivens, Kenneth E. Greer, James W. Patterson, Frank T. Saulsbury
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?