Clinical and histopathologic observations of the action of imiquimod in an epithelioid hemangioendothelioma and Paget’s mammary disease - 09/08/11
, Maria I. Martínez, MD c, Martin C. Mihm, MD a
Reprint requests: Ignacio Sanchez-Carpintero, MD, PhD, Department of Dermatology, Clínica Universitaria de Navarra, Pio XII, 36, 31080 Pamplona, Spain.Boston, Massachusetts; Pamplona, Spain; and San Juan, Puerto Rico
Abstract |
An epithelioid hemangioendothelioma and Paget’s disease of the breast were treated with topical imiquimod 5% cream with very impressive results. In both of the tumors complete disappearance of the lesions occurred. In this article, in addition to describing the treatment approach, the findings in biopsy specimens of the epithelioid hemangioendothelioma and the Paget’s disease before, during, and after therapy will be described. The histologic findings show ample evidence that there is both a lymphocytic T helper 1-like and T helper 2-like response from imiquimod. Direct evidence of lymphocytotoxicity was found. Furthermore, mast cells appear to be involved in the development of regression in the vascular tumor. Although the study is very limited and reports only two cases, the results are striking. We considered it important to describe these findings because of their possible use in developing strategies for the application of imiquimod in the treatment of other tumors in human beings.
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| Funding sources: None. Disclosure: Drs Mihm and Sanchez-Carpintero were awarded research funding from 3M Pharmaceuticals after this study. There is a patent pending of imiquimod use that did not apply when the article was originally written or when the treatment was being performed. Presented in part as a poster at the World Congress in Dermatology in Paris, France, July 2002. |
Vol 55 - N° 1
P. 75-79 - juillet 2006 Retour au numéro
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