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Journal of the American Academy of Dermatology
Volume 54, n° 6
pages 933-946 (juin 2006)
Doi : 10.1016/j.jaad.2005.08.062

Chemoprevention of nonmelanoma skin cancer

Tina I. Wright, MD a, James M. Spencer, MD b, Franklin P. Flowers, MD a,
a From the University of Florida College of Medicine 
b Mount Sinai School of Medicine 

Correspondence to: Frank P. Flowers, MD, PO Box 100264, Gainesville, FL 32610.

Gainesville, Florida, and New York, New York


Skin cancer is the most common cancer in human beings. The increased incidence of skin cancer has brought much attention to the process by which these tumors develop and how they can be prevented. Efforts have been made to educate the public about the importance of protecting skin from excessive ultraviolet light. Despite this work, the incidence of skin cancer continues to increase. Available compounds may be useful in the chemoprevention of skin cancer. Chemoprevention is defined as oral or topical use of dietary or pharmacologic agents to inhibit or reverse the development of cancer. Potential agents included are the retinoids; difluoromethylornithine; T4 endonuclease V; polyphenolic antioxidants, such as (−)-epigallocatechin gallate, found in green tea and grape seed extract; silymarin; isoflavone genestein; nonsteroidal anti-inflammatory drugs; curcumin; lycopene; vitamin E; beta-carotene; and selenium. Many of these agents are available over the counter as topical or oral preparations.

Learning objective

At the conclusion of this activity, participants should be familiar with the chemopreventive agents and their efficacy, as well as any significant side effects associated with them.

The full text of this article is available in PDF format.

Abbreviations used : BCC, COX, DFMO, NMSC, ODC, SCC, TAG, UV, XP

 Funding source: An educational grant of $1,000, provided to the first author by the American Academy of Dermatology, funded a month of mentorship with both the second and third authors.
Conflict of interest: None identified.
Reprints not available from the authors.

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