Lipid abnormalities are prevalent in youth with type 1 and type 2 diabetes: The search for diabetes in youth study - 09/08/11
, Stephen R. Daniels, MD, PhD, Giuseppina Imperatore, MD, PhD, Shana L. Palla, MS, Diana B. Petitti, MD, MPH, David J. Pettitt, MD, Santica Marcovina, PhD, ScD, Lawrence M. Dolan, MD, Richard F. Hamman, MD, DrPH, Angela D. Liese, PhD, Catherine Pihoker, MD, Beatriz L. Rodriguez, MD, PhD
Reprint requests: Dr Ann Kershnar, Kaiser Permanente Southern California, 9449 East Imperial Highway, Downey, CA 90242Résumé |
Objective |
Assessment of the prevalence of serum lipid abnormalities in US youth with type 1 or type 2 diabetes.
Study design |
The SEARCH for Diabetes in Youth Study was a cross-sectional, population-based study, conducted in six centers. Subjects were 2448 youth with diabetes who had a study examination. Outcome measures were fasting measures of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and non–HDL-C. Analysis was descriptive.
Results |
The overall prevalence of high TC concentration (>240 mg/dL) was 5%; the overall prevalence of high LDL-C (>160 mg/dL) was 3%, and the overall prevalence of high triglyceride (>400 mg/dL) was 2%. About half of the participants (48%) had an LDL-C concentration above the optimal level of 100 mg/dL. Among youth ages 10+, the prevalence of abnormal lipids was higher in type 2 (n = 283) than in type 1 diabetes (n = 1963): 33% versus 19% had TC concentration >200 mg/dL; 24% versus 15% had LDL-C concentration >130 mg/dL; 29% versus 10% had triglyceride concentration >150 mg/dL; 44% versus 12% had HDL-C concentration <40 mg/dL. Only 1% of youth were receiving pharmacologic therapy for dyslipidemia.
Conclusions |
A substantial proportion of young patients with diabetes have abnormal serum lipids.
Le texte complet de cet article est disponible en PDF.Abbreviations : ADA, AHA, BMI, HDL-C, LDL-C, NCEP, NHANES, TC
Plan
| SEARCH for Diabetes in Youth was supported by the Centers for Disease Control and Prevention (PA No. 00097) and the National Institute of Diabetes and Digestive and Kidney Diseases. The findings and conclusions in this report are those of the authors and do not represent the view of the funding agency. |
Vol 149 - N° 3
P. 314-319 - septembre 2006 Retour au numéro
Article précédent
- Mechanical ventilation of very low birth weight infants: Is volume or pressure a better target variable?
- Jaideep Singh, Sunil K. Sinha, Paul Clarke, Steve Byrne, Steven M. Donn
- Coronary artery calcification, serum lipids, lipoproteins, and peripheral inflammatory markers in adolescents and young adults with type 1 diabetes
- Peter Gunczler, Roberto Lanes, Arlette Soros, Livia Verdu, Yolanda Ramon, Beatriz Guevara, Nusen Beer
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?