A multicenter prospective randomized trial of corticosteroids in primary therapy for Kawasaki disease: Clinical course and coronary artery outcome - 09/08/11
, Yasunori Okada, MD, Makoto Shinohara, MD, Tohru Kobayashi, MD, Tomio Kobayashi, MD, Takeshi Tomomasa, MD, Kazuo Takeuchi, MD, MPH, Akihiro Morikawa, MDGunma Kawasaki Disease Study Group
Reprint requests: Yoshinari Inoue, Department of Pediatrics and Developmental Medicine, Gunma University Graduate School of Medicine, 3-29-22, Showa-machi, Maebashi, Gunma 371-8511, Japan.Résumé |
Objective |
To investigate the role of corticosteroids in the initial treatment of Kawasaki disease (KD).
Study design |
Between September 2000 and March 2005, we randomly assigned 178 KD patients from 12 hospitals to either an intravenous immunoglobulin (IVIG) group (n = 88; 1 g/kg for 2 consecutive days) or an IVIG plus corticosteroid (IVIG+PSL) group (n = 90). The primary endpoint was coronary artery abnormality (CAA) before a 1-month echocardiographic assessment. Secondary endpoints included duration of fever, time to normalization of serum C-reactive protein (CRP), and initial treatment failure requiring additional therapy. Analyses were based on intention to treat.
Results |
Baseline characteristics of groups were similar. Fewer IVIG+PSL patients than IVIG patients had a CAA before 1 month (2.2% vs 11.4%; P = .017). The duration of fever was shorter (P < .001) and CRP decreased more rapidly in the IVIG+PSL group than in the IVIG group (P = .001). Moreover, initial treatment failure was less frequent (5.6% vs 18.2%; P = .010) in the IVIG+PSL group. All patients assigned to the IVIG+PSL group completed treatment without major side effects.
Conclusions |
A combination of corticosteroids and IVIG improved clinical course and coronary artery outcome without causing untoward effects in children with acute KD
Le texte complet de cet article est disponible en PDF.Abbreviations : CAA, CRP, IV, IVIG, KD, PSL
Plan
Vol 149 - N° 3
P. 336 - septembre 2006 Retour au numéro
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