Probiotics in the prevention of antibiotic-associated diarrhea in children: A meta-analysis of randomized controlled trials - 09/08/11
, Marek Ruszczyński, MD, Andrzej Radzikowski, MD
Reprint requests: H. Szajewska, MD, Department of Paediatric Gastroenterology and Nutrition, The Medical University of Warsaw, 01-184 Warsaw, Dzialdowska 1, Poland.Résumé |
Objective |
To systematically evaluate the effectiveness of probiotics in preventing antibiotic-associated diarrhea (AAD) in children.
Study design |
The following electronic databases up to December 2005, in any language, were searched for studies relevant to AAD and probiotics: MEDLINE, EMBASE, and The Cochrane Library. Only randomized controlled trials (RCT) were considered for study inclusion.
Results |
Six placebo-controlled, RCTs (766 children) were included. Treatment with probiotics compared with placebo reduced the risk of AAD from 28.5% to 11.9% (relative risk, RR, 0.44, 95% CI 0.25 to 0.77, random effect model). Preplanned subgroup analysis showed that reduction of the risk of AAD was associated with the use of Lactobacillus GG (2 RCTs, 307 participants, RR 0.3, 95% CI 0.15 to 0.6), S. boulardii (1 RCT, 246 participants, RR 0.2, 95% CI 0.07-0.6), or B. lactis & Str. thermophilus (1 RCT, 157 participants, RR 0.5, 95% CI 0.3 to 0.95).
Conclusions |
Probiotics reduce the risk of AAD in children. For every 7 patients that would develop diarrhea while being treated with antibiotics, one fewer will develop AAD if also receiving probiotics.
Le texte complet de cet article est disponible en PDF.Abbreviations : AAD, CI, DDD, NNT, RCT, RR
Plan
Vol 149 - N° 3
P. 367 - septembre 2006 Retour au numéro
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