Benzoyl peroxide/clindamycin/UVA is more effective than fluticasone/UVA in progressive macular hypomelanosis: A randomized study - 09/08/11
Reprint requests: W. Westerhof, MD, PhD, Netherlands Institute for Pigment Disorders, Meibergdreef 35, 1105 AZ Amsterdam, The Netherlands.Amsterdam and Rotterdam, The Netherlands
Abstract |
Background |
There is no effective treatment for progressive macular hypomelanosis. Recent findings indicate that Propionibacterium acnes may play a role in the pathogenesis.
Objectives |
We sought to compare the effectiveness of antimicrobial therapy with anti-inflammatory therapy in patients with progressive macular hypomelanosis.
Methods |
A total of 45 patients were randomized to a within-patient left-right comparison study of benzoyl peroxide 5% hydrogel/clindamycin 1% lotion in combination with UVA irradiation versus fluticasone 0.05% cream in combination with UVA irradiation. Repigmentation was determined by photometric measurements of changes in skin color and by patient and dermatologist assessment using before and after photographs.
Results |
Benzoyl peroxide 5% hydrogel, clindamycin 1% lotion, and UVA led to better repigmentation than fluticasone 0.05% cream in combination with UVA irradiation in all measurements. (Photometric measurements P = .007, patient assessment P < .0001, and dermatologist assessment P < .0001.)
Limitations |
There was difficult objective color measurement. Therefore, subjective assessment has important additional value. Right-left comparisons have certain inherent limitations.
Conclusion |
Antimicrobial therapy in conjunction with light was more effective in repigmentation in patients with progressive macular hypomelanosis than a combination of anti-inflammatory therapy and light.
Le texte complet de cet article est disponible en PDF.Abbreviations used : bcUVA, CIE, fUVA, PMH
Plan
| Funding sources: None. Conflicts of interest: None identified. |
Vol 55 - N° 5
P. 836-843 - novembre 2006 Retour au numéro
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