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Joint Bone Spine
Volume 72, n° 4
pages 295-302 (juillet 2005)
Doi : 10.1016/j.jbspin.2004.12.010
Received : 2 February 2004 ;  accepted : 15 December 2004
Monosodium urate and calcium pyrophosphate dihydrate (CPPD) crystals, inflammation, and cellular signaling
 

Ru Liu-Bryan a, , Frédéric Lioté b
a Veteran Affairs Medical Center, University of California, MC111K, 3350 La Jolla Village Drive, San Diego, CA 92161, USA 
b Inserm U606, Centre Viggo Petersen, Hôpital Lariboisière (Assistance Publique-Hôpitaux de Paris), Paris 7 University, Paris, France 

*Corresponding author.

Supported by research grants from the NIH (RO3-AR-49416-10) and the Stein Institute for Research on Aging (RLB), and from Inserm, and the Université Paris 7 (FL)

Abstract

Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals are responsible for acute synovial inflammation but also contribute to cartilage degradation and bone lesions within the joint. They activate multiple signal transduction pathways leading to cell activation and recruitment. Some signalling pathways are activated by both types of crystals, and other pathways may only be activated by one type depending on cell type, namely neutrophils, monocytes, macrophages, synovial fibroblasts, endothelial cells and chondrocytes. Cascades of activated proteins involve cytoplasmic membrane related proteins (FAK complex, Src family tyrosine kinases), but also MAPK and NF-kB pathways, leading to NO, prostanoid and cytokine production, and protease activation. This review will also focus on potential therapeutic targets related to cellular signalling in MSU and CPPD crystal-induced inflammation.

The full text of this article is available in PDF format.

Keywords : Monosodium urate, Calcium pyrophosphate dihydrate, Cellular signaling, Crystal, Arthritis, Inflammation




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