The use of oral midazolam for perioperative anxiolysis of healthy patients undergoing Mohs surgery: Conclusions from randomized controlled and prospective studies - 10/08/11
, Pamela K. Phillips, MD b, Randall K. Roenigk, MD b, Amy L. Weaver b, Jill M. Killian b, Alyssa Hoverson Schott, MD b, Clark C. Otley, MD b
Reprint requests: Larisa Ravitskiy, MD, Ohio State University, Division of Dermatology, 2050 Kenny Rd, 4th Floor Tower, Columbus, OH 43221.Abstract |
Background |
Anxiety can complicate any outpatient procedure by causing elevation in blood pressure and heart rate with resultant increase in intraoperative and postoperative bleeding. Anxiety may also reduce patient satisfaction with the surgical experience. Midazolam is an efficacious short-acting benzodiazepine with an excellent safety record. However, little experience is documented on the use of midazolam in outpatient dermatologic surgery.
Objective |
To establish the safety and efficacy of oral midazolam in healthy patients undergoing Mohs micrographic surgery.
Methods |
Patients undergoing outpatient Mohs surgery were randomized in a double-blind, placebo-controlled study of single-dose midazolam for efficacy and safety in producing anxiolysis of short duration. A subpopulation of patients was evaluated prospectively in a nonrandomized arm of the study. Data on vital signs, anxiety, adverse events, and overall satisfaction were collected and compared using analysis of covariance model.
Results |
Forty-four patients were randomized and 31 patients were enrolled in the prospective arm. Socioeconomic and surgical characteristics were similar among the groups. At 60 minutes, there was a clinically and statistically significant reduction in anxiety and alertness in both randomized and prospective arms. There were no major adverse events. Patients in all 3 groups were equally satisfied with their experience.
Limitations |
Few patients with high perioperative anxiety were willing to participate in a randomized controlled trial of anxiolytic medication.
Conclusions |
Midazolam is safe and efficacious in perioperative anxiolysis for healthy patients undergoing outpatient Mohs micrographic surgery. Midazolam offers the benefits of amnesia, reduced alertness, and reduced blood pressure with no clinically significant adverse effects.
Le texte complet de cet article est disponible en PDF.Key words : anxiety, anxiolysis, BCC, hypoxia, midazolam, Mohs surgery, SCC, visual analog scale
Abbreviations used : MMS, MMSE, NMSC, pM, pOx, rM, VAS
Plan
| Funding sources: None. |
|
| Conflicts of interest: None declared. |
Vol 64 - N° 2
P. 310-322 - février 2011 Retour au numéro
Article précédent
- Mobile teledermatology in the developing world: Implications of a feasibility study on 30 Egyptian patients with common skin diseases
- Kathleen Tran, Mohamed Ayad, Jennifer Weinberg, Augustin Cherng, Mridul Chowdhury, Saadeddin Monir, Mohamed El Hariri, Carrie Kovarik
- Correlation between histologic findings on punch biopsy specimens and subsequent excision specimens in recurrent basal cell carcinoma
- Klara Mosterd, Monique R.T.M. Thissen, Arienne M.W. van Marion, Patty J. Nelemans, Bjorn G.P.M. Lohman, Peter M. Steijlen, Nicole W.J. Kelleners-Smeets
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?