“Clark/dysplastic” nevi with florid fibroplasia associated with pseudomelanomatous features - 10/08/11
, Jean L. Bolognia, MD, Earl J. Glusac, MD
Reprint requests: Christine J. Ko, 333 Cedar St, PO Box 208059, New Haven, CT 06520.Abstract |
Background |
Melanocytic nevi may exhibit histologic features in common with cutaneous melanoma, creating diagnostic difficulties.
Objective |
We sought to assess the clinical behavior of melanocytic nevi with pseudomelanomatous features in association with dermal fibrosis.
Methods |
Forty-two melanocytic nevi with pronounced fibrosis and associated pseudomelanomatous changes were collected and studied clinically and histologically.
Results |
The fibrosis was centrally located and laminated in appearance. It imparted a trizonal appearance: a junctional component with prominent single cells and/or irregular nests, underlying fibrosis, and a mature dermal component. No recurrence or metastases were evident over an average follow-up period of 2 years.
Limitations |
The follow-up period was short.
Conclusions |
The central location and laminated appearance of the fibrosis suggest that this may represent the extreme end of a spectrum of fibroplastic changes in “Clark/dysplastic” nevi. Adjacent features of “Clark/dysplastic” nevi and limitation of pseudomelanomatous features to the perifibrotic focus are important in accurately identifying these lesions. Although melanocytic nevi with exaggerated fibroplasia may show foci with melanoma-like features, they do not appear to exhibit aggressive clinical behavior.
Le texte complet de cet article est disponible en PDF.Key words : Atypical nevus, Clark nevus, dysplastic nevus, fibroplasia, melanoma, pseudomelanoma, sclerosing nevus
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 64 - N° 2
P. 346-351 - février 2011 Retour au numéro
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