Infectious agents in cutaneous T-cell lymphoma - 10/08/11
Abstract |
Infectious agents have long been suspected as potential causative agents in cutaneous T-cell lymphoma (CTCL). Tissues of patients with CTCL have been evaluated for evidence of infection with a number of agents, including Staphylococcus aureus, retroviruses, and herpesviruses. These studies have failed to reveal a consistent association of CTCL with investigated agents. However, there is substantial evidence suggesting a potential role of a yet unidentified virus in CTCL. This article will review the findings of studies exploring potential roles of infectious agents in CTCL. In addition, we investigated CTCL tissues for evidence of infection with Merkel cell polyomavirus, a novel polyomavirus that was recently discovered as a probable carcinogenic agent in Merkel cell carcinoma. Cutaneous lesions demonstrating mycosis fungoides were stained with a monoclonal antibody against the Merkel cell polyomavirus T antigen, along with appropriate positive and negative controls. Immunohistochemical stains produced negative results in all examined mycosis fungoides specimens. These findings, which suggest a lack of association of CTCL with Merkel cell polyomavirus, add to the current body of knowledge regarding infectious agents and CTCL.
Le texte complet de cet article est disponible en PDF.Key words : cutaneous T-cell lymphoma, Epstein-Barr virus, herpesvirus, human T-lymphotrophic virus, infection, Merkel cell polyomavirus, retrovirus
Abbreviations used : CMV, CTCL, EBV, HHV, HTLV, KSHV, MCC, MCV, MF, PCR, SS, TCR
Plan
Funding sources: None. |
|
Conflicts of interest: None declared. |
Vol 64 - N° 2
P. 423-431 - février 2011 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?