Correlation between insulin-like growth factor binding protein-3 serum level and melanoma progression - 10/08/11
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, Antimo Naspi, MD b, , Valeria Devirgiliis, MD a, Michela Curzio, MD a, Vincenzo Roberti, MD a, Gianfranca Curzio, BS b, Silvia Gobbi, MD a, Stefano Calvieri, MD, Prof a, Paola Londei, MD, Prof bReprint requests: Vincenzo Panasiti, MD, Department of Dermatology, University of Rome “Sapienza,” Viale del Policlinico, 155, 00161 Rome, Italy.Abstract |
Background |
Insulin-like growth factor (IGF) binding protein (IGFBP)-3 is the main carrier of circulating IGFs and the main modulator of their activity. IGFBP-3 controls cellular availability of IGFs, which cannot exert their pro-proliferative activity while bound to IGFBP-3. Proteolysis of IGFBP-3 is one mechanism to control IGF release. A reduction of serum IGFBP-3 levels and the associated increased availability of IGFs may represent a strategy whereby melanoma increases its metastatic potential.
Objective |
The aim of our study was to evaluate the correlation between the IGFBP-3 serum level and melanoma stage.
Methods |
The study included 41 patients, 24 male and 17 female, with median age of 60 years (range 24-80), affected by cutaneous melanoma. Blood samples were taken from each patient and IGFBP-3 serum levels were measured using Western blot analysis with commercial antibodies. Values were normalized using commercial IGFBP-3.
Results |
The statistical analysis showed that full-size, glycosylated IGFBP-3 concentrations were significantly lower in the sera of patients with stage IV melanoma. Low serum levels of IGFBP-3 correlated with both disease progression and presence of disease at the time of sample collection. In patients who underwent follow-up visits with further collections of blood samples, the concentrations of glycosylated IGFBP-3 decreased only in those who showed progression of disease.
Limitations |
Our study shows only preliminary results on a limited number of patients.
Conclusion |
We demonstrate that there is a significant inverse correlation between the serum concentration of full-size, glycosylated IGFBP-3 and disease progression in patients with melanoma.
Le texte complet de cet article est disponible en PDF.Key words : disease progression, insulin-like growth factors, insulin-like growth factor binding protein-3, melanoma, melanoma serum biomarkers, tumor-produced proteases
Abbreviations used : AJCC, IGF, IGFBP
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 64 - N° 5
P. 865-872 - mai 2011 Retour au numéro
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