Photoprotective effects of a broad-spectrum sunscreen in ultraviolet-induced cutaneous lupus erythematosus: A randomized, vehicle-controlled, double-blind study - 10/08/11
, Kristina Gensch, MD b, Merle Haust, MD b, Anna-Maria Meuth, MA a, France Boyer, MD c, Patrick Dupuy, MD c, Percy Lehmann, MD d, Dieter Metze, MD a, Thomas Ruzicka, MD e
Reprint requests: Annegret Kuhn, MD, Department of Dermatology, University of Muenster, Von-Esmarch-Strasse 58, D-48149 Muenster, Germany.Abstract |
Objective |
We sought to assess if the exclusive use of a broad-spectrum sunscreen can prevent skin lesions in patients with different subtypes of cutaneous lupus erythematosus (CLE) induced by ultraviolet (UV) irradiation under standardized conditions.
Methods |
A total of 25 patients with a medical history of photosensitive CLE were included in this monocentric, randomized, vehicle-controlled, double-blind, intraindividual study. The test product and its vehicle were applied 15 minutes before UVA and UVB irradiation of uninvolved skin areas on the upper aspect of the back in a random order, and standardized phototesting was performed daily for 3 consecutive days.
Results |
Characteristic skin lesions were induced by UVA and UVB irradiation in 16 patients with CLE in the untreated area, and 14 patients showed a positive test result in the vehicle-treated area. In contrast, no eruptions compatible with CLE were observed in the sunscreen-treated area in any of the 25 patients. This resulted in significant differences (P < .001) between UV-irradiated sunscreen-treated versus vehicle-treated areas, and between UV-irradiated sunscreen-treated versus untreated areas. Furthermore, a significant difference (P < .05) was observed concerning the age of disease onset and the patient history of photosensitivity. Patients who were younger than 40 years at onset of CLE reported photosensitivity significantly more often than patients with a higher age of disease onset. None of the patients showed any adverse events from application of the test product or the vehicle.
Limitations |
Data resulting from standardized experimental phototesting might not be transferable to a clinical setting.
Conclusion |
These results indicate clearly that the use of a highly protective broad-spectrum sunscreen can prevent skin lesions in photosensitive patients with different subtypes of CLE.
Le texte complet de cet article est disponible en PDF.Key words : autoimmunity, cutaneous lupus erythematosus, photoprotection, photosensitivity, sunscreen, ultraviolet irradiation
Abbreviations used : ACR, CLE, DLE, LE, LET, PLE, SCLE, SLE, UV
Plan
| Supported by the Institut de Recherche Pierre Fabre and by a Heisenberg Scholarship from the German Research Foundation to Dr Kuhn (KU 1559/1-2). |
|
| Conflicts of interest: Dr Boyer and Dr Dupuy were both employees of Pierre Fabre Dermo-Cosmétique at the time of the study conduct, which is the owner of the sunscreen product under investigation in this study. Drs Kuhn, Gensch, Haust, Meuth, Lehmann, Metze, and Ruzicka declared no conflict of interest. |
Vol 64 - N° 1
P. 37-48 - janvier 2011 Retour au numéro
Article précédent
- American Board of Dermatology Examination Dates
- Staphylococcus epidermidis: A possible role in the pustules of rosacea
- Margot Whitfeld, Nishmi Gunasingam, Liang Joo Leow, Kyoko Shirato, Veronica Preda
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?