Neurosensory Impairment after Surgical Closure of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants: Results from the Trial of Indomethacin Prophylaxis in Preterms - 11/08/11
, Robin S. Roberts, MSc, Lex W. Doyle, MD, Luann Papile, MD, Avroy Fanaroff, MDTrial of Indomethacin Prophylaxis in Preterms (TIPP) Investigators
Reprint requests: Barbara Schmidt, MD, MSc, McMaster University, HSC 3N11E, 1200 Main St W, Hamilton, ON, Canada L8N 3Z5.Résumé |
Objectives |
To determine whether surgical closure of a patent ductus arteriosus (PDA) is a risk factor for bronchopulmonary dysplasia (BPD), severe retinopathy of prematurity (ROP), and neurosensory impairment in extremely low birth weight (ELBW) infants.
Study design |
We studied 426 infants with a symptomatic PDA, 110 of whom underwent PDA ligation and 316 of whom received medical therapy only. All infants participated in the multicenter Trial of Indomethacin Prophylaxis in Preterms (TIPP) and were observed to a corrected age of 18 months.
Results |
Of the 95 infants who survived after PDA ligation, 50 (53%) had neurosensory impairment, compared with 84 of the 245 infants (34%) who survived after receiving only medical therapy (adjusted odds ratio, 1.98; 95% CI, 1.18-3.30; P = .0093). BPD (adjusted odds ratio, 1.81; 95% CI, 1.09-3.03; P = .023) and severe ROP (adjusted odds ratio, 2.20; 95% CI, 1.19-4.07; P = .012) were also more common after surgical PDA closure.
Conclusions |
PDA ligation may be associated with increased risks of BPD, severe ROP, and neurosensory impairment in ELBW infants.
Le texte complet de cet article est disponible en PDF.Abbreviations : BPD, ELBW, PDA, ROP, TIPP
Plan
| Supported by the Medical Research Council of Canada MT-13288. US centers were supported in part by grants from the National Institute of Child Health and Human Development (D U10 HD21364, U10 HD27851, U10 HD21373, U10 HD27881; M01 RR 00997, U10 HD27880; M01 RR 00070, U10 HD21385, U10 HD27904, U10 HD34216). INDOCID P.D.A. was donated by Merck Frosst. |
Vol 150 - N° 3
P. 229 - mars 2007 Retour au numéro
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