Efficacy, predictors of response, and long-term follow-up in patients with vitiligo treated with narrowband UVB phototherapy - 12/08/11
Reprint requests: Andreas D. Katsambas, MD, 35 Skoufa Str, GR-10673 Athens, Greece.Athens, Greece
Abstract |
Background |
Narrowband UVB (NB-UVB) phototherapy is considered an accepted therapy for vitiligo.
Objective |
We sought to estimate the effectiveness of NB-UVB in patients with vitiligo, identify predictive factors of response, and assess the stability of NB-UVB–induced repigmentation.
Methods |
In all, 70 patients with vitiligo were treated twice weekly with NB-UVB.
Results |
Cosmetically acceptable (>75%) repigmentation was achieved in 34.4% of patients with lesions on the face and in 7.4% of patients with lesions on the body. Patients with phototypes III to V had a greater chance to achieve greater than 75% repigmentation on the face. Patients who responded in the first month of treatment were more likely to achieve better repigmentation rates. Repigmentation was stable in 14.3% of patients 4 years after cessation of treatment.
Limitations |
The study was uncontrolled. Treatment frequency was twice weekly. These results may not be representative of different treatment regimens.
Conclusion |
Patients with vitiligo who have lesions on the face, darker phototypes, and early response to treatment have a greater chance to achieve satisfactory repigmentation after NB-UVB phototherapy.
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| Funding sources: None. Conflicts of interest: None identified. Presented at the 15th Congress of the European Academy of Dermatology and Venereology, Rhodes, Greece, on October 4-8, 2006. |
Vol 56 - N° 2
P. 274-278 - février 2007 Retour au numéro
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