Lichenoid paraneoplastic pemphigus in the absence of detectable antibodies - 12/08/11
Baltimore, Maryland; Petah Tikva and Tel Aviv, Israel; and Fort Sam Houston, Texas
Abstract |
Paraneoplastic pemphigus (PNP) has been described as an antibody-mediated mucocutaneous disease occurring almost exclusively in patients with lymphocytic neoplasms. We describe 4 patients with the clinical features of the lichenoid variant of PNP in the absence of detectable autoantibodies. On the basis of these findings, we conclude that the spectrum of PNP likely includes patients with disease predominantly or exclusively mediated by cytotoxic T cells rather than autoantibodies. The pathophysiology and range of PNP disease are likely more complex than was initially believed.
Le texte complet de cet article est disponible en PDF.Abbreviations used : CLL, CT, DIF, IIF, IL, NHL, PNP
Plan
Funding sources: None. Conflicts of interest: None identified. The opinions contained herein are the private views of the authors and are not to be construed as reflecting the views of the US Department of Defense. |
Vol 56 - N° 1
P. 153-159 - janvier 2007 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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