Methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis presenting in the skin - 12/08/11
, Jacqueline Junkins-Hopkins, MD a, John T. Seykora, MD, PhD a, Donald J. Adler, DO b, Rosalie Elenitsas, MD a
Reprint requests: Loren E. Clarke, MD, Department of Pathology H179, The Penn State/Milton S. Hershey Medical Center, Hershey, PA 17033.Philadelphia, Pennsylvania
Abstract |
A 91-year-old woman who had been taking methotrexate for approximately 5 years for rheumatoid arthritis developed papules and nodules on her face that enlarged during 6 months. A series of biopsy specimens demonstrated a lymphoplasmacytic infiltrate with increasingly atypical histopathologic features that resembled diffuse large B-cell lymphoma. Epstein-Barr virus was not identified. Withdrawal of methotrexate resulted in complete resolution of all lesions within 8 weeks. This case illustrates the rare occurrence of methotrexate-associated lymphoproliferative disorder with primary presentation in the skin and documents clinical and histopathologic progression from early changes to fully developed lesions.
Le texte complet de cet article est disponible en PDF.Abbreviations used : DLBCL, EBV, HL, IR, LPD, MTX, RA
Plan
| Funding sources: None. Conflicts of interest: None identified. |
Vol 56 - N° 4
P. 686-690 - avril 2007 Retour au numéro
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