Sebaceous gland loss and inflammation in scarring alopecia: A potential role in pathogenesis - 13/08/11
Reprint requests: Stephen Lyle, MD, PhD, Departments of Cancer Biology and Pathology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605.Abstract |
Background |
Primary scarring alopecia (SA) comprises a group of disorders with poorly defined origins. Improving diagnostic and therapeutic capabilities requires a better understanding of their pathogenesis.
Objectives |
We sought to assess the frequency of sebaceous gland loss in SA and to identify the role of sebaceous gland and sebaceous gland duct inflammation in the pathogenesis of SA.
Methods |
Ninety specimens submitted with a clinical history of alopecia, both scarring and nonscarring, were reviewed. Samples were scored based on sebaceous gland, sebaceous duct, and follicle inflammation.
Results |
Sebaceous gland loss was much more common in cases of SA (>53% of follicles on average) than non-SA (<5% of follicles on average). Many cases of SA showed residual affected follicles with an absence of sebaceous glands. Sebaceous gland duct inflammation was often more frequent and severe than gland inflammation in SA.
Limitations |
Sample size was limited in some alopecia entities. Inflammation was graded by means of subjective observation.
Conclusions |
This study demonstrates that sebaceous gland loss is a common and early finding among SA. In addition, sebaceous gland and/or duct inflammation may play a role in initiating or accelerating follicular damage during the development of SA.
Le texte complet de cet article est disponible en PDF.Key words : pathogenesis, pathology, scarring alopecia, sebaceous gland
Abbreviations used : AA, AG, AKN, FD, FDS, LPP, SA, TA, TE, TT
Plan
| Funding sources: None. |
|
| Conflicts of interest: None declared. |
Vol 65 - N° 3
P. 597-603 - septembre 2011 Retour au numéro
Article précédent
- Dermatopathologic effects of taxane therapy
- Rebecca S. Plummer, Christopher R. Shea
- De novo melanoma and melanoma arising from pre-existing nevus: In vivo morphologic differences as evaluated by confocal microscopy
- Caterina Longo, Cintia Rito, Francesca Beretti, Anna Maria Cesinaro, Juan Piñeiro-Maceira, Stefania Seidenari, Giovanni Pellacani
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?