Treatment of non-albicans Candida vaginitis with amphotericin B vaginal suppositories - 18/08/11
Reprint requests: Albert J. Phillips, MD, 1301 20th St, Suite 270, Santa Monica, CA 90404.Abstract |
Objective |
This study was undertaken to investigate whether amphotericin B vaginal suppositories would be effective in the treatment of non-albicans Candida vaginitis in women who failed conventional therapy.
Study design |
Thirty-two patients were identified with non-albicans Candida vaginitis. These patients were treated with conventional antifungal agents. Ten patients had persistence of the non-albicans Candida infection after treatment. Amphotericin B 50-mg vaginal suppositories were given nightly for 14 days to this subgroup of treatment failures.
Results |
Of 10 women, 8 (80%) who were treated with amphotericin B vaginally initially showed no further infection. One of the treatment successes had 2 recurrences and responded to a second course of amphotericin B but failed a third course. If this patient is considered a treatment failure, then amphotericin B vaginal suppositories were successful in 70% of patients. The medication was well tolerated and local side effects were minimal.
Conclusion |
Amphotericin B vaginal suppositories are a viable treatment option for refractory vaginitis caused by non-albicans Candida.
Le texte complet de cet article est disponible en PDF.Key words : Amphotericin B, Vaginitis, Non-albicans Candida
Plan
| Presented at the 71st Annual Meeting of the Pacific Coast Obstetrical and Gynecological Society, October 19-24, 2004, Phoenix, Ariz. |
Vol 192 - N° 6
P. 2009-2012 - juin 2005 Retour au numéro
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