Thymoma-associated multiorgan autoimmunity: A graft-versus-host–like disease - 19/08/11
Abstract |
Graft-versus-host disease (GVHD) is a T cell–mediated disease seen most commonly after hematopoietic stem cell transplantation. Rarely, a GVHD-like disease can be seen in patients with malignant thymoma. We describe a 50-year-old man with malignant thymoma who developed skin, liver, and intestinal manifestations similar to that seen in GVHD. We also review other reported cases of GVHD-like manifestations in the setting of thymoma and propose “thymoma-associated multiorgan autoimmunity” as a name for this novel disease. Specifically, thymoma-associated multiorgan autoimmunity is defined as a disease of the liver, intestine, or skin, which on histopathology resembles GVHD but is seen in the setting of malignant thymoma and not after hematopoietic stem cell transplantation.
Le texte complet de cet article est disponible en PDF.Abbreviations used : GVHD, HSCT, MHC, Ta, TAMA
Plan
A. Wadhera coordinated the dermatologic treatment of the patient and prepared Table I. E. Maverakis wrote the manuscript, collected data for the publication, and coined the new disease name TAMA. P. Lynch proposed GVHD as the patient’s diagnosis and collected data for the publication. M. Fung interpreted the dermatopathology. N. Mitsiades served as a source of technical expertise and helped in revising the manuscript. P. Lara was the oncologist. He served as a source of technical expertise. All authors proofed the manuscript and made suggestions during its preparation. |
|
Funding sources: None. |
|
Conflicts of interest: None declared. |
Vol 57 - N° 4
P. 683-689 - octobre 2007 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?