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Journal of the American Academy of Dermatology
Volume 57, n° 4
pages 722-724 (octobre 2007)
Doi : 10.1016/j.jaad.2007.05.013
Commentary

Expanding the microcomedone theory and acne therapeutics: Propionibacterium acnes biofilm produces biological glue that holds corneocytes together to form plug
 

Craig G. Burkhart, MD, MPH a, b, Craig N. Burkhart, MD, MSBS c
a University of Toledo School of Medicine, Sylvania, Ohio 
b Ohio University College of Osteopathic Medicine, Sylvania, Ohio 
c Department of Pediatric Dermatology, Northwestern University, Chicago, Illinois 

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The Propionibacterium acnes biofilm has previously been shown to exist via genomic studies and to make a biological glue which allows for adherence to follicular walls. This gylcocalyx polymer secreted by P acnes also finds its way into sebum composition where it causes the adhesiveness of keratinocytes leading to comedones. An appreciation of P acnes biofilms and secretions has implications in immunogenicity of the organism, clinical course of acne, and therapy for comedonal and inflammatory acne.

The full text of this article is available in PDF format.

 Funding sources: None.
 Conflicts of interest: None declared.
 Reprints not available from the authors.
 Correspondence to: cgbakb@aol.com.


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