Abnormal keratin expression in circumscribed palmar hypokeratosis - 19/08/11
Tokyo and Saitama, Japan
Abstract |
Background |
Circumscribed palmar or plantar hypokeratosis (CPH) is a rare skin disorder only recently described.
Objective |
To determine the diagnostic features and to provide insight into the pathogenesis of CPH, with analysis of two new Japanese cases.
Methods |
Dermoscopy, immunohistochemistry, electron microscopy, polymerase chain reaction amplification for human papillomavirus (HPV) DNA and 16S microbial rRNA gene profiling were conducted.
Results |
Dermoscopy showed characteristic features using both dry and jelly immersion observation; step-like desquamation and a homogeneous erythema with regularly distributed whitish spots. Immunohistochemistry revealed strong staining with anti-pankeratin antibody (AE1+AE3) and anti-keratin 16 antibody, and decreased expression of keratin 2e. EM revealed a breakage of the corneocytes within their cytoplasm, but structures for cell attachment were intact. HPV and lesion-specific bacteria were not detected.
Limitations |
The number of cases analyzed was two.
Conclusion |
Hyperproliferative epidermal state along with enhanced corneocyte fragility may account for the unique features in CPH.
Le texte complet de cet article est disponible en PDF.Abbreviations used : CPH, EM, HPV, PCR, rRNA
Plan
Supported in part by Grants-in Aid for Scientific Research (C) (18591258) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. Conflicts of interest: None declared. |
Vol 57 - N° 2
P. 285-291 - août 2007 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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