Intractable wounds caused by calcific uremic arteriolopathy treated with bisphosphonates - 19/08/11
, Mamori Tani, MD, Noriko Umegaki, MD, PhD, Yukari Nishimura, MD, Ichiro Katayama, MD, PhD
Reprint requests: Yuji Yamaguchi, MD, PhD, Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.Abstract |
Background |
Calcific uremic arteriolopathy (calciphylaxis) is a calcification syndrome that predominantly affects relatively small vessels and is a life-threatening entity usually seen in patients with end-stage renal disease. Intractable skin necrosis sometimes causes lethal sepsis because it progresses rapidly as a result of mechanical stress.
Objective |
We sought to investigate the efficacy of etidronate disodium (bisphosphonates) in treating intractable ulcers occurred in a patient on hemodialysis accompanied with calcific uremic arteriolopathy.
Methods and Results |
A 53-year-old patient receiving hemodialysis with chronic renal failure accompanied with calciphylaxis had bilateral leg ulcers caused by minor trauma. The aggressive debridement worsened his skin condition as is usually seen in pyoderma gangrenosum. It eventually healed by lowering calcium-phosphorus levels with the administration of bisphosphonates and with the continuous use of sevelamer hydrochloride.
Limitations |
This study reporting a single case limits the interpretation of results.
Conclusion |
Bisphosphonates may be effective in treating calciphylaxis and arteriosclerosis obliterans by reducing the formation of ectopic calcification around blood vessels.
Le texte complet de cet article est disponible en PDF.Plan
| Supported in part by the Osaka Medical Research Foundation for Incurable Diseases, the Lydia O’Leary Memorial Foundation, a SHISEIDO Grant for Science Research, and a grant-in-aid from the Ministry of Education, Culture, Sports, Science, and Technology. |
|
| Conflicts of interest: None declared. |
Vol 57 - N° 6
P. 1021-1025 - décembre 2007 Retour au numéro
Article précédent
- Eligibility creep: A cause for placebo group improvement in controlled trials of psoriasis treatments
- Jeff Hick, Steven R. Feldman
- Detection of spirochetal micro-organisms by focus-floating microscopy in necrobiotic xanthogranuloma
- Bernhard Zelger, Klaus Eisendle, Christian Mensing, Bettina Zelger
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?