Research Criteria for the Diagnosis of Birdshot Chorioretinopathy: Results of an International Consensus Conference - 19/08/11
, Antoine Brezin, MD, PhD b, Aniki Rothova, MD, PhD c, Massimo Accorinti, MD d, Gary N. Holland, MD a
Inquiries to Ralph D. Levinson, MD, Jules Stein Eye Institute, 100 Stein Plaza, UCLA, Los Angeles, CA 90095-7000Résumé |
Purpose |
To present and evaluate research criteria for the diagnosis of birdshot chorioretinopathy.
Design |
Consensus statement.
Methods |
Investigators who attended an international conference on birdshot chorioretinopathy drafted diagnostic criteria, which were refined after comment by conference attendees. Sensitivity and specificity of the criteria were evaluated by review of 82 previously diagnosed cases and evaluation of 80 consecutive patients with other forms of uveitis.
Results |
Criteria, including presence of “birdshot lesions” and mild intraocular inflammation in both eyes, are based on clinical findings in the absence of systemic disease; HLA-A29 is supportive of diagnosis, but not required. Diagnostic criteria were found to be 100% specific and 97.5% sensitive. Positive predictive value was 100%; negative predictive value was 97.6%.
Conclusions |
Standardized criteria for the diagnosis of birdshot chorioretinopathy will facilitate clinical research and the comparison of results from studies performed at different institutions by ensuring a homogeneous population of study patients.
Le texte complet de cet article est disponible en PDF.| This study was supported by the Association d’Ophtalmologie de Cochin, Paris, France (A.B.), Research to Prevent Blindness (RPB), Inc, New York, New York (G.N.H.), the MacDonald Foundation, Los Angeles, California (R.D.L.), the Skirball Foundation, Los Angeles, California (G.N.H.), and the David May II Endowed Professorship (G.N.H.). Additional support was provided by the Emily Plumb Estate and Trust Gift for resources used in the Jules Stein Eye Institute Clinical Research Center. Dr Holland is recipient of an RPB Physician-Scientist Award. |
Vol 141 - N° 1
P. 185-187 - janvier 2006 Retour au numéro
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