Treatment of Herpes Simplex Virus Stromal Keratitis Unresponsive to Topical Prednisolone 1% With Topical Cyclosporine 0.05% - 19/08/11
Inquiries to Sanjay N. Rao, MD, University of Chicago, 5841 S Maryland MC 2114, Chicago, IL 60605Résumé |
Purpose |
To assess the efficacy of topical cyclosporine 0.05% (Restasis) in patients with herpes simplex virus nonnecrotizing stromal keratitis unresponsive to topical prednisolone.
Design |
Prospective case series.
Methods |
Patients with herpes simplex virus stromal keratitis (n = 12) that was unresponsive to topical prednisolone acetate 1% for at least four weeks were evaluated at a single site. Eyes were treated with topical cyclosporine twice a day and begun on a rapid prednisolone taper. Visual acuity, slit-lamp appearance, intraocular pressure, and corneal sensitivity were evaluated every two weeks for at least three months.
Results |
Stromal keratitis resolved with cyclosporine in 10 of 12 patients after one month. The mean lesion area decreased more with cyclosporine than with prednisolone (2.0 mm with cyclosporine compared with 0.25 mm with prednisolone). After stopping cyclosporine therapy, four patients had recurrence of stromal keratitis.
Conclusion |
This series suggests that herpes simplex virus stromal keratitis can be treated effectively with topical cyclosporine, particularly in cases that are not responsive to topical prednisolone.
Le texte complet de cet article est disponible en PDF.Plan
| Supported in part by an unrestricted grant from Research to Prevent Blindness. |
Vol 141 - N° 4
P. 771-772 - avril 2006 Retour au numéro
Article précédent
- Nonprogressive Extrafoveal Retinal Hole After Foveal Epiretinal Membrane Removal
- Igor Kozak, William R. Freeman
- Restrictive Horizontal Strabismus Following Blepharoplasty
- Malcolm L. Mazow, Cynthia W. Avilla, Hector J. Morales
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?